Intersectional approaches may be relevant in studies involving human subjects. While sex and gender are important concepts to consider, they are shaped by other social and biological factors. Gender identities, norms, and relations both shape and are shaped by other social attributes. Sex often interacts with gender while being intersected by factors such age, race, socioeconomic status, geographic location, language, or religion.

For example, as far as brain development is concerned, those social and cultural factors interfere with the interaction between sex attributes (such as genes, chromosomes, or hormones) and gender attributes (such as parental stimuli, formal education, or the media).